DIVISION OF NEPHROLOGY

Faculty

Dr. Mazen ArarMazen Y. Arar, MD
Division chief and professor of pediatrics
Division of Nephrology
210-562-5365

Education:
M.B.B.S., University of Jordan, Amman, Jordan, 1980

Training:
Internship, pediatrics, Jordan University Hospital, 1980-81
Residency, pediatrics, Jordan University Hospital, 1981-84
Fellowship, pediatric nephrology, UT Southwestern Medical Center, Dallas, 1989-92
Residency, pediatrics, UT Southwestern Medical Center, Dallas, 1992-93
Fellowship, nephrology research, UT Southwestern Medical Center, Dallas, 1993-94

Board of Certification:
Pediatrics, 1993; Pediatric Nephrology, 1999

Selected Publications:

  • Jones T, Ye F, Bedolla R, Huang Y, Meng J, Qian L, Pan H, Zhou F, Moody R, Wagner BT, Arar MY. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J Clin Invest 2012 Mar;22(3):1076-1081.
  • Velagapudi C, Nilsson RP, Lee MJ, Burns HS, Ricono JM, Arar MY, Barnes VL, Abboud HE, Barnes JL. Reciprocal Induction of Simple Organogenesis by Mouse Kidney Progenitor Cells in Three-Dimensional Co-Culture. Am J Pathol 2011 Dec
  • Gipson DS, et al, Arar MY. Clinical trial of focal segmental glomerulosclerosis in children and young adults. Kidney Int 2011 Jul
  • McDonald RA, Smith JM, Ho M, Lindblad R, Ikle D, Grimm P, Wyatt R, Arar MY, Liereman D, Bridges N, Harmon W. Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. Am J Transplant 2008 May;8(5):984-989.
  • Warady B, Arar MY, Lerner G, Nakanishi A, Stehman-Breen C. Darbepoetin alfa for the treatment of anemia in pediatric patients with chronic kidney disease. Pediatr Nephrol 2006 Aug;21(8):1144-1152.
  • Ye P, Habib SL, Ricono JM, Kim NH, Ghosh-Choudhury G, Barnes JL, Abboud HE, Arar MY. Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Kidney International 2004;66:1356-1364.
  • Arar MY, Xu Y, Elshihabi I, Barnes JL, Ghosh-Choudhury G, Abboud HE. Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells. J Biol Chem 2000;275:9527-9533.

Interests:

  • Clinical – End stage renal disease, kidney transplantation, hypertension, and fluid and electrolyte management
  • Basic Research - Expertise in basic research methods are utilized to establish a basic research programs in renal development and physiology. Research projects are focused on the role of growth factors in the development of mesangial cell, and the role of fibronectin, an extracellular matrix protein, on ureteric bud cell branching morphogenesis. Other research projects utilized radioactive phosphate transport in animals and cell culture. These studies examined the maturation of phosphate transport in rabbits and effects of epidermal growth factor on phosphate transport in both OK cells and animals. The following research procedures are well established in my laboratory: small animal handling and anesthesia, cell culture, tissue culture, three-dimensional gel culture, cell adhesion assay, cell proliferation and migration assays, microscopic dissection and isolation of small animals' embryonic kidneys, northern blot, western blot, southern blot, immunohistochemistry, receptor binding and kinetic assay studies.

 

Dr. Daniel RanchIkuyo Yamaguchi, MD, PhD
Assistant Professor of Pediatrics
Division of Nephrology
210-562-5365

Education:
M.D., Kumamoto University School of Medicine, Kumamoto, Japan, 1987
Ph.D., Kurume University, Kurume-Shi, Japan, 1994

Training:
Residency, pediatrics, Kurume University, Kurume City, Japan, 1987 – 1990
Residency, pediatrics, Georgetown University Hospital, Washington, DC, 1999 - 2002
Fellowship, pediatric nephrology, Seattle Children’s Hospital, Seattle, WA, 2003 - 2006

Board of Certification:
Pediatrics - Japan, 1991; Pediatrics, 2003; Pediatric Nephrology, 2008

Recent Publications:

Articles:

  • Kida Y, Tchao BN, Yamaguchi I. Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease. Pediatr Nephrol (EPub ahead of print) 2014 Mar
  • Okamura DM, Bahrami N, Pasichnyk K, Williams J, Gangoiti JA, Lopez-Guisa JM, Yamaguchi I, Barshop BA, Eddy AA. Cysteamine modulates oxidative stress and blocks myofibroblast activity during chronic kidney injury J Am Soc Nephrol 2014 Jan;25(1):43-54.
  • Yamaguchi I, Tchao BN, Burger Ml, Yamada M, Hyodo T, Giampietro C, Eddy AA. Vascular Endothelial Cadherin Modulates Renal Interstitial Fibrosis Nephron Exp Nephrol 2012;120(1):e20-e31.
  • Lopez-Guisa JM, Cai S, Collins SJ, Yamaguchi I, Okamura DM, Bugge TH, Isacke CM, Emson CL, Turner SM, Shankland SJ, Miner JH, Eddy AA. Mannose receptor 2 promotes collagen turnover and attenuates renal fibrosis in experimental chronic kidney disease J Am Soc Nephrol 2012;23(2):236-251.
  • Eddy AA, Lopez-Guisa JM, Okamura DM, Yamaguchi I. Investigating mechanisms of chronic kidney disease in mouse models Pediatr Nephrol 2012;27(8):1233-1247.

Book Chapters:

  • Eddy AA, Yamaguchi I. Chronic tubulointerstitial nephritis In: Schrier’s Diseases of the Kidney, 9th Edition. Lippincott Williams & Wilkins; 2012. p. 1626 - 1658.

Interests:

  • Clinical - Hypertension, Chronic Kidney Disease. 
  • Basic Research - The overall goal of my studies was to understand the roles of the renal microcirculation in kidney injury, focusing on the mechanisms and functional impact of peritubular capillary loss in chronic kidney disease (CKD). Long-term goals of this line of research are to identify pharmacological approaches to preserve peritubular capillaries, and to determine whether saving capillaries can limit renal fibrosis. I recently published a study (funded by a K08 from NIDDK) showing that vascular endothelial cadherin (VE-cadherin), an endothelial-specific adhesion molecule, has roles in renal fibrosis and the control of renal vascular permeability. The VE-cadherin data add to a growing body of evidence suggesting that the renal microcirculation plays an active role in fibrosis. I also pursued studies to identify other molecular targets with the potential for therapeutic modulation of capillary loss, using microRNA and mRNA arrays to detect endothelial cell-specific changes in a mouse model of CKD. This led to the identification of microRNA-155 as a potential regulator of endothelial cell activation in CKD. I also obtained preliminary data showing effects of Matrix Gla Protein (MGP), an inhibitor of bone morphogenetic proteins, in chronic kidney injury. These data suggested that MGP plays a protective role, limiting peritubular capillary rarefaction and fibrosis.

 

Dr. Daniel RanchDaniel Ranch, MD
Assistant Professor of Pediatrics
Division of Nephrology
210-562-5365

Education:
M.D., Chulalongkorn University Faculty of Medicine, Bangkok, Thailand, 2003

Training:
Internship, pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, 2004-2005
Residency, pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, 2005-2007
Fellowship, pediatric nephrology, University of California San Francisco, San Francisco, CA 2007-2010

Board of Certification:
Pediatrics, 2007; Pediatric Nephrology, 2012

Recent Publications:

  • Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F. Chronic Inhibition of ERK1/2 Signaling Improves Disordered Bone and Mineral Metabolism in Hypophosphatemic (Hyp) Mice Endocrinology 2012 Apr;153(4):1806-1816.
  • Ranch D, Zhang MYH, Portale AA, Perwad F. Fibroblast Growth Factor-23 Regulates Renal 1,25(OH)2D and Phosphate Metabolism via the MAP Kinase Signaling Pathway in Hyp Mice Journal of Bone and Mineral Research 2011 Aug
  • Ranch D, Aigbe MO, Gorospe EC. Prenatal calcification of the inferior vena cava and renal veins in a normal neonate. ScientificWorldJournal 2006 Jun;6:734-736.

Interests:
Chronic kidney disease, mineral bone disorders, cardiovascular disease, and kidney transplantation. 

 

Ivette JonesIvette Jones, RN, MSN, CPNP
Clinical Instructor of Pediatrics
Division of Nephrology
210-562-5365

Education:
B.S.N., University of Texas at El Paso, El Paso, Texas 2001
M.S.N., University of Texas at El Paso, El Paso, Texas 2010

Board of Certification:
Pediatric Nurse Practitioner, 2010

Interests:
Management of children with chronic renal disease, dialysis, and/or renal transplantation.