DIVISION OF NEONATOLOGY

Research

Research Facilities
A variety of research facilities are available to the Division of Neonatology:

  1. 1100 square feet of laboratory space equipped for molecular biology and cellular physiology investigation
  2. Separate laboratory for small animal ventilation; equipped with a computer monitored premature rabbit ventilator system (capable of ventilating 20 premature rabbits simultaneously)
  3. Animal care and laboratory facilities for neonatal specialty resident’s bench research projects in UTHSCSA facilities
  4. Access to Laboratory Animal Resources for primate research
  5. Resources for clinical research include the University Hospital NICU, a 30,000 square foot facility.  Within the perimeter of the NICU clinical research is facilitated by:
  6. A clinical laboratory staffed by 24 hours/day technicians to perform blood gas, glucose, bilirubin, hematocrit, and electrolyte analyses
  7. A pharmacy staffed 54 hours/week and equipped with controlled temperature refrigerator and freezer
  8. A 250-square foot research laboratory
  9. Dedicated equipment for performing and imaging digital radiographs
  10. Dedicated supple and respiratory therapy facilities
  11. Separate office facilities for neonatal faculty and residents equipped with separate desktop computers and internet access
  12. Conference rooms and parent education rooms
  13. A dedicated elevator connecting the NICU to labor and delivery, one floor below
  14. Electronic bedside medical charting

 

Recent Publications
Reeves AA, Johnson CJ, Vasquez MM, Maheshwari A, Blanco CL. TGF-2, a protective intestinal cytokine, is abundant in maternal human milk and human-derived fortifiers but not in donor human milk Breastfeeding Medicine 2013 Jul

DelliFraine J, Langabeer J 2nd, Delgado R, Williams JF, Gong A. A Transition Strategy for Becoming a Baby-Friendly Hospital: Exploring the Costs, Benefits, and Challenges Breastfeeding Medicine 2013 Apr;:170-175.

Moreira A, February M, Geary C. Parathyroid Hormone Levels in Neonates with Suspected Osteopenia Journal of Paediatric Child Health 2013 Jan;49(1):E12-E16.

Namachivayam K, Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez MM, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weikamp JH, Seidner SR, Maheshwari A. Smad7 inhibits autocrine expression of TGF-2 in intestinal epithelial cells in baboon necrotizing enerocolitis Am J Physiol Gastrointest Liver Physiol 2013 Jan;304(2):G167-180.

Blanco CL, McGill-Vargas L, McCurnin D, Quinn A. Hyperglycemia Increases the Risk of Death in Extremely Preterm Baboons Pediatric Research 2013 Mar;73(3):337-343.

Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez M, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weitkamp JH, Seidner S, Maheshwari A. Smad7 inhibits autocrine expression of TGF-B2 in intestinal epithelial cells in baboon necrotizing enterocolitis Am J Physiol Gastrointest 2013 Jan;15:167-180.

Shah S, Moreira A, Moreira AG. Sterile Cerebrospinal Fluid Pleocytosis in an Infant With Appendicitis Clin Pediatr (Phila) 2012 Nov;.

Quinn AR, Blanco CL, Perego C, Finzi G, La Rossa S, Capella C, Guardado-Mendoza R, Casiraghi F, Gastaldelli A, Johnson M, Dick EJ, Folli F. The ontogeny of the endocrine pancreas in the fetal/newborn baboon J Endocrinology 2012 Sep;14(3):289-299.

Sutherland MR. Yoder BA. McCurnin D. Seidner S. Gubhaju L. Clyman RI. Black MJ. Effects of ibuprofen treatment on the developing preterm baboon kidney Am J Physiol Renal Physiol 2012 May;302(10):F1286-F1292.

Ghandehari H, Lee ML, Rechtman DJ; H2MF Study Group. An exclusive human milk-based diet in extremely premature infants reduces the probability of remaining on total parenteral nutrition: a reanalysis of the data BMC Res Notes 2012 Apr;25(5).

Griffith JL, Shimony JS, Cousins SA, Rees SE, McCurnin DC, Inder TE, Neil JJ. MR imaging correlates of white-matter pathology in a preterm baboon model Pediatr Res 2012 Feb;71(2):185-191.

Blanco CL, Gong AK, Daniels, W, Liechty, E, Schoolfield, J, Ramamurthy RS, Green, BK. The Impact of Early High Amino Acid Supplementation on ELBW Infants at Two Years Journal of Pediatric Gastroenterology & Nutrition 2012 Jan;54:601-607.

Moreira AG, Rouce R, Richardson CJ, Jain SK. A premature neonate with leukocytosis Journal of Clinical Pediatrics 2012 Jan;.

Moreira AG, Ahmed M, Shah S. A newborn with bilateral hand and foot deformities NeoReviews: Visual Diagnosis 2012 Jan;.

Moreira AG, Caskey M, Fonseca R, Malloy M, Geary C. Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants a historical cohort study The Journal of Maternal-Fetal & Neonatal Medicine 2012 Jan

Moreira AG, Diego A, Fonseca R. Bilateral pedal edema in a newborn NeoReviews: Index of Suspicion 2012 Jan

Jupelli M, Murthy AK, Chaganty BK, Guentzel MN, Selby DM, Vasquez MM, Mustafa SB, Henson BM, Seidner SR, Zhong G, Arulanandam BP. Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life Lab Invest 2011 Oct;91:1530-1539.

Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R, Seidner SR. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment J Pediatr 2011 Jun;158(6):919-923.

Blanco CL, Gong AK, Green BK, Falck A, Schoolfield J, Liechty EA. Early changes in plasma amino acid concentrations during aggressive nutritional therapy in extremely low birth weight infants J Pediatr 2011 Apr;158(4):543-548.

DelliFraine J, Langabeer J, Williams JF, Gong AK, Delgado RI, Gill SL. Cost comparison of baby friendly and non-baby friendly hospitals in the United States Pediatrics 2011 Apr;127(4):989-994.

Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman RI. Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons Pediatr Res 2011 Mar;69(3):212-216.

Moreira AG, Swischuck L, Jain SK. Tachypnea and oxygen desaturation with bottle feeding NeoReviews: Index of Suspicion 2011 Jan

Bishop, Christine E, Vasquez MM, Petershack JA, Blanco CL. Pasteurized Donor Human Milk for VLBW Infants: The Effects on Necrotizing Enterocolitis and Related Factors Journal of Neonatal-Perinatal Medicine 2010 Jun;3(2):87-93.

Loeliger M, Shields A, McCurnin D, Clyman RI, Yoder B, Inder TE, Rees SM, McCurnin DC. Ibuprofen Treatment for Closure Of Patent Ductus Arteriosus Is Not Associated With Increased Risk Of Neuropathology Pediatr Res 2010 Jun;.

Blanco CL, Hanyu L, Joya-Galeana J, DeFronzo M, McCumin D, Musi N. The ontogeny of insulin signaling in the preterm baboon model Endocrinology 2010 May;151(5):1990-1997.

Kompass KS, Deslee G, Moore CH, McCurnin D, Pierce RA, McCurnin DC. Highly conserved transcriptional responses to mechanical ventilation of the lung Physiol Genomics 2010 May;.

Sandra Sullivan MDa, Richard J. Schanler MD, a, , Jae H. Kim MD, PhDa, Aloka L. Patel MDa, Rudolf Trawger MDa, Ursula Kiechl-Kohlendorfer MDa, Gary M. Chan MDa, Cynthia L. Blanco MDa, Steven Abrams MDa, C. Michael Cotten MD, MHSa, Nirupama Laroia MDa, Richard A. Ehrenkranz MDa, Golde Dudell MDa, Elizabeth A. Cristofalo MD, MPHa, Paula Meier PhDa, Martin L. Lee PhDa, David J. Rechtman MDa and Alan Lucas MDa. An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products The Journal of Pediatrics 2010 Apr;156(4):562-567.e1.
Moreira AG, Ahmed M. Bowed limbs in a newborn NeoReviews: Visual Diagnosis 2010 Jan

Odom MW, Carbonell-Estrany X, Simoes E, Dagan R, Hall CB, et al. Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk children: A noninferiority Trial Pediatrics 2010 Jan;125(1):e35-e51.

Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI, McCurnin DC. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency Pediatr Res 2010 Jan;68(4):292-297.

McAdams RM, Winter VT, McCurnin DC, Coalson JJ. Complications of umbilical artery catheterization in a model of extreme prematurity J Perinatol 2009 Oct;29(10):685-692.

Vasquez MM, German VF, Scott AA, Foulds DM, Blanco CL. Neonatal Lead Intoxication Following Maternal Pica: A Case Report and Review of the Literature Journal of Neonatal-Perinatal Medicine 2009 Jul;2(2):123-126.

Lin AE, OBrien B, Demmer LA, Almeda KK, Blanco CL, Glasow PF, Berul CI, Hamilton R, Micheil Innes A, Lauzon JL, Sol-Church K, Gripp KW. Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia Prenat Diagn 2009 Jul;29(7):682-690.

Vasquez MM, Mustafa SB, Choudary A, Seidner SR, Castro R. Regulation of Epithelial Na+ Channel (ENaC) in the Salivary Cell Line SMG-C6 Experimental Biology and Medicine 2009 May;234(5):522-531.

McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia Am J Respir Crit Care Med 2009 Mar;179(6):492-500.

Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation Pediatr Res 2009 Mar;65(3):285-290.

Leoliger M, Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM. Developmental and neuropathological consequences of ductal ligation in the preterm baboon Pediatric Research 2009 Feb;65(2).

Lin AE, OBrien B, Demmer LA, Almeda KK, Blanco CL, Glasow PF, Berul CI, Hamilton R, Innes M, Lauzon JL, Sol-Church K, Gripp KW. Prenatal features of Costello syndrome: Ultrasonographic findings and atrial tachycardia Prenatal Diagnosis 2009 Jan;29:682-690.

Powers GC,Ramamurthy RS, Schoolfield J, Matula, K. Postdischarge Growth and Development in a Predominantly Hiaspanic, Very Low Birth Weight Population Pediatrics 2008 Dec;122:1258-1265.

McCurnin DC, Clyman RI. Effects of patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons Pediatrics 2008 Dec;122(6):e1262-e1267.

Vasquez MM, Castro R, Seidner SR, Henson BM, Ashton DJ, Mustafa SB. Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC J Cell Physiol 2008 Dec;217(3):632-642.

Blanco CL, Falck A, Green BK, Cornell JA, Gong AK. Metabolic Responses to Early and High Protein Supplementation in a Randomized Trial Evaluating the Prevention of Hyperkalemia in ELBW Infants The Journal of Pediatrics 2008 Oct;153(4):535-540.

J. Isaac, R.J. DiGeronimo, P.S. Dixon, B.M. Henson and S.B. Mustafa. Mechanical stretch upregulates alpha-epithelial Na+ channel (alpha-ENaC) expression in murine lung epithelial (MLE-12) cells via MAPK activation Pediatric Research 2008 Jul;

McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang ZM, Clyman RI, Petershack JA. Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung Pediatrics 2008 May;121(5):945-956.

Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR. Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC) J Cell Physiol 2008 Apr;215(1):101-110.