DIVISION OF IMMUNOLOGY & INFECTIOUS DISEASES

Faculty

Allergy and Immunology

Infectious Diseases

Tumor Virology Program

Allergy and Immunology

Dr. Anthony InfanteAnthony J. Infante, M.D., Ph.D.

Division chief, professor of pediatrics and associate chairman for research

Director, Children's Immunology Clinic

E-mail: infantea@uthscsa.edu

210-567-0510

Education:

M.D., Indiana University, 1978

Ph.D., biological chemistry, Indiana University, 1977

B.S., chemistry, Ball State University, 1972

Training:

Fellowship, immunology, Stanford University, 1981-83

Fellowship, immunology, Mayo Foundation, 1980-81

Residency, pediatrics, Mayo Clinic

Board Certification:

Pediatrics, 1989, 1997, 2004

Recent Publications:

Standifer, NE, Stacy S, Kraig E, Infante AJ. Discrete T cell populations with specificity for a neo-self-antigen bear distinct imprints of tolerance. Journal of Immunology 2007;178:3544-3550.

Standifer NE, E Kraig, AJ Infante. A hierarchy of T cell receptor motifs determines responsiveness to the immunodominant epitope in experimental autoimmune myasthenia gravis. J Neuroimm 2003;145(1-2):68-76.

Stacy S, BE Gelb, BA Koop, JJ Windle, KA Wall, KA Krolick, AJ Infante, E Kraig. Split tolerance in a novel transgenic model of autoimmune myasthenia gravis. J Immun 2002;169(11):6570-6579.

Interests:

Primary immune deficiency diseases, T-cell receptor repertoire development, immune reconstitution, autoimmune diseases, myasthenia gravis.

 

Dr. Edward BrooksDr. Edward Brooks

Assistant professor of pediatrics

E-mail: brookse@uthscsa.edu

210-567-5250

Education:

M.D., Texas Tech University School of Medicine, 1985

B.S., chemistry, Washington & Lee University, Lexington, Virginia, 1981

Training:

Postdoctoral fellowhsip, pathology, Harvard University, 1991-93

Clinical fellowship, allergy and immunology, UT Medical Branch, Galveston, 1988-91

Residency, pediatrics, UT Medical Branch, Galveston, 1985-88

Board Certification:

Pediatrics, 1990; Pediatric allergy & immunology, 1991

Publications:

Sullivan J, Petronella S, Brooks E, Murillo M, Primeau L, Ward J, Brooks EG. Theatre of the oppressed and environmental justice communities: a transformational therapy for the body politic. J Health Psychol 2008 Mar;13(2):166-179.
=Thaller EI, Petronella SA, Hochman D, Howard S, Chhikara RS, Brooks EG. Moderate increases in ambient PM2.5 and ozone are associated with lung function decreases in beach lifeguards. J Occup Environ Med 2008 Feb;50(2):202-211.
Zaitsu M, Narita S, Lambert KC, Grady JJ, Estes DM, Curran EM, Brooks EG, Watson CS, Goldblum RM, Midoro-Horiuti T. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol 2007 Mar;44(8):1977-1985.


Infectious Diseases

Dr. Charles LeachCharles Leach, M.D.

Professor of pediatrics

E-mail: leachc@uthscsa.edu

210-567-5250

Education:

M.D., University of Utah, Salt Lake City, 1982

B.A., chemistry, Point Loma College, San Diego, 1976

Training:

Fellowship, pediatric infectious diseases, University of California, Los Angeles, 1986-89

Residency, pediatrics, University of California, Los Angeles, 1984-86

Internship, pediatrics, University of California, Los Angeles, 1983-84

Fellowship, genetics, Veteran's Administration Hospital, Salt Lake City, 1982-83

Board Certification:

Pediatrics, 1987; Pediatric Infectious Diseases, 1994

Recent Publications:

Leach CT, Behrman RE, Kliegman RM, Jenson HB. Roseola (Human Herpesviruses 6 and 7) In: W.B. Saunders Co. Textbook of Pediatrics (18th edition). Philadelphia: 2007.

Leach CT, Behrman RE, Kliegman RM, Jenson HB. Human Herpesvirus 8 In: W.B. Saunders. Textbook of Pediatrics (18th edition). Philadelphia: 2007.

Interests:

Epidemiology of human herpesvirus-6 and -8 infections, Antiviral trials for viral infections in children, Emerging infections along the Texas-Mexico border, Genetic susceptibility to infection, Infectious etiologies for prostate cancer and Infectious etiologies for cardiovascular disease


Dr. Dennis ConradDennis Conrad, M.D.

Professor of pediatrics

E-mail: conradd@uthscsa.edu

210-567-5250

Education:

M.D., Ohio State University, 1978

B.A., zoology, Ohio State University, 1975

Training:

Fellowship, pediatric infectious disease, Oklahoma Children's Memorial Hospital, 1983-86

Residency, pediatrics, chief resident, Children's Medical Center, UTHSC-Southwestern Medical School, Dallas, 1981-82

Residency, pediatrics, Parkland Memorial Hospital, UTHSC-Southwestern Medical School, Dallas, 1978-81

Board Certification:

Pediatrics, 1984; Pediatric Infectious Diseases, 1994

Recent Publications:

Conrad DA. Medical Management of Acute Sinusitis In: Brook I (ed). Sinusitis: From Microbiology to Management. New York: Marcel Dekker, Inc.; 2006. p. 203 - 217.

Gallardo MJ, Johnson DA, Gaviria J, Nguyen L, Melendez R, Connor DA, Conrad DA. Isolated herpes simplex keratoconjunctivitis in a neonate born by cesarean delivery. J AAPOS 2005 Jun;9(3):285-287

Conrad DA. Immunizations In: Yamamoto LG, Inaba AS, Okamoto JK, Patrinos ME, Yamashiroya VK (eds). Case Based Pediatrics for Medical Students and Residents. Bloomington: AuthorHouse, Inc.; 2004. p. 8-14.

Interests:

Anti-Infective, Vaccine-preventable infections


Dr. Terence DoranTerence Doran, M.D., Ph.D.

Professor of pediatrics

Medical Director, South Texas Family AIDS Network

E-mail: DORANT@UTHSCSA.EDU

210-567-7400

Education:

M.D., UT Health Science Center Medical School, San Antonio, 1984

Ph.D., microbiology, UT Health Science Center Graduate School of Biomedical Sciences, San Antonio, 1981

B.S., biology, Southwest Texas State University, 1971

Training:

Fellowship, pediatric infectious diseases, UT Health Science Center, San Antonio, 1988-90

Residency, pediatrics, Bexar County Teaching Hospitals, San Antonio, 1986-89

Internship, pediatrics, Bexar County Teaching Hospitals, San Antonio, 1985-86

Board Certification:

Pediatrics, 1989; Pediatric Infectious Diseases, 1994

Recent Publications:

Doran TI. Teens Living With HIV San Antonio Medicine 2006 Jul;59(7):26-28.

Arbona SI, Melville SK, Hanson IC, Squires JE, Doyle M, Doran TI, Patel JA, Handal GA, Hauger SB, Murphey DK, Dominguez K. Mother-to-child transmission of the human immunodeficiency virus in Texas. Pediatr Infect Dis J 2001 Jun;20(6):602-606.

Parra EO, Doran TI, Ivy LM, Aranda JM, Hernandez C. Concerns of pregnant women about being tested for HIV: a study in a predominately Mexican-American population. AIDS Patient Care STDS 2001 Feb;15(2):83-93.

Interests:

My professional interest is in the medical care of children, with particular interest in the diagnosis and treatment of children and adolescents with infectious diseases, especially those with HIV/AIDS. I have a strong interest in education of medical residents and students about all aspects of pediatrics, especially clinical teaching (clinic and hospital) about diseases and management of diseases of children, with special interest in education about HIV. I also am interested in education of health care professionals, and lay persons about all aspects of HIV and STDs.


Tumor Virology Program

Dr. SHou-Jiang GaoShou-Jiang Gao, Ph.D.

Professor of Pediatrics, Microbiology and Medicine

Program Leader, Tumor Virology Program

Children's Cancer Research Institute

210-562-9030

Education:

Ph.D., microbiology, molecular and cellular biology, University of Bordeaux, Bordeaux, France, 1993

M.S.C., biochemistry, South China Agricultural University, Guangzhou, China, 1987

B.S., biochemistry, South China Agricultural University, Guangzhou, China, 1984

Recent Publications:

Zhang YJ and Gao S-J. Molecular identification of new infectious agents and emerging drug-resistant pathogens In: M. Olive (ed.). Emerging Infections. 2007.

Mutlu AD, Cavallin LE, Vincent L, Chiozzini C, Eroles P, Duran EM, Asgari Z, Hooper AT, La Perle KM, Hilsher C, Gao SJ, Dittmer DP, Rafii S, Mesri EA, Gao S. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi‘s sarcoma. Cancer Cell 2007 Mar;11(3):245-258.

Pan HY, Xie JP, Ye FC, and Gao SJ. Modulation of KSHV infection and replication by MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways during primary infection J Virol 2006 Jun;80(11):5371-5382.

Interests:

AIDS-related Malignancies, Angiogenesis, Cancer Biology, Herpesvirus, Kaposi's sarcoma, Molecular and Cellular Biology, Signal transduction, Tumor Virology, Virology

 

Dr. Alakesh Bera

Postdoctoral fellow


Fengchun Ye PhDFengchun Ye, Ph.D.

Assistant professor

210-562-9034

Education:

Ph.D., molecular microbiology, University of Bordeaux, Bordeaux, France, 1993

M.S., molecular microbiology, University of Bordeaux, Bordeaux, France, 1990

M.S., plant genetics, HuaZhong Agricultural University, Wuhan City, China, 1988

B.S., horticulture and plant science, HuaZhong Agricultural University, Wuhan City, China, 1984

Recent Publications:

Yoo SM, Zhou FC, Ye FC, Pan HY, Gao SJ, Ye F. Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 2005 Dec;343(1):47-64.

Yoo SM, Zhou F, Ye F, Pan HY, Gao S. Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 2005 Dec;343(1):47-64.

Ye FC, Zhou FC, Yoo SM, Xie JP, Browning PJ, Gao SJ, Gao S. Disruption of Kaposi‘s Sarcoma-Associated Herpesvirus Latent Nuclear Antigen Leads to Abortive Episome Persistence. J Virol 2004 Oct;78(20):11121-11129.

Interests:

Molecular mechanisms of virus pathology - Identification of virus and host genes that are responsible for tumor development, tumor growth, and tumor angiogenesis. Functional analysis of virus genes that are involved in virus replication and genome maintenance.


Fuchun Zhou, Ph.D.

Assistant professor of pediatrics

210-562-9035

Education:

Ph.D., virology, HuaZhong Agricultural University, Wuhan City, China, 1998

D.V.M., veterinarian medicine, HuaZhong Agricultural University, Wuhan City, China, 1992

Recent Publications:

Yoo SM, Zhou F, Ye F, Pan HY, Gao S. Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 2005 Dec;343(1):47-64.

Ye FC, Zhou FC, Yoo SM, Xie JP, Browning PJ, Gao SJ, Gao S. Disruption of Kaposi‘s Sarcoma-Associated Herpesvirus Latent Nuclear Antigen Leads to Abortive Episome Persistence. J Virol 2004 Oct;78(20):11121-11129.

Pan HY, Zhou F, Gao S. Kaposi‘s Sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells Cancer Research 2004 Jun;64(12):4064-4068.

 

Dr. LeiXiufen Lei, M.D., Ph.D.
Instructor
Tumor Virology Program

210-562-9044

Education:

Ph.D., epidemiology, Beijing Medical University, China, 1994

M.S., environmental health, Shanxi Medical University, China, 1991

M.D., preventive medicine, Shanxi Medical University, China, 1988

Publications:

Lei X, Bai Z, Ye F, Zhou F, Gao SJ. Expression and functions of KSHV microRNAs 2007 Aug. (the 10th international workshop on Kaposi's Sarcoma associated herpesvirus(KSHV) and related agents).
Lei X, Sun L. Estrogen Suppresses the DNA Mismatch Repair Activity in Human Estrogen Receptor Positive Breast Cancer Cells 2005 Apr. (Proceedings of 96th Annual meeting of American Association for Cancer Research, Anaheim, CA, Abstract #1785).
Lei X, Sun L. Estrogen Suppresses the DNA Mismatch Repair Activity in Human Estrogen Receptor Positive Breast Cancer Cells 2004 Nov. (The 13th Annual Symposium on Cancer Research in San Antonio and South Texas, Abstract #27. First Prize for postdoctoral fellows).

 

Gabriela Lacatus, Ph.D.

Faculty associate/postdoctoral fellow

Tumor Virology Program